Written by Annika Dahlqvist on 17 June, 2006 at 20:50
http://www.nutritionandmetabolism.com/content/3/1/22
In Karlshamn study (by Jörgen Vesti Nielsen and others) a group of 16 people with Type-2 diabetes were to eat low carbohydrate diet by 20 % of carbohydrates, another group had to eat the recommended low lipid/high carbohydrate diet.
At 6 and 12 month follow-up the low carbohydrate group had much better result in body weight and blood sugar.
Now at 22 month follow-up, results are still much better for low carbohydrate group. Moreover, two thirds of high carbohydrate group also switched to low carbohydrate group, and then they have improved in their values. Accordingly, this long-term study which the dietary establishment demanded is here!
Regina Wilshire http://weightoftheevidence.blogspot.com/ tells in her blog today about an interview made with Daniel G Clark, spokesperson for the ADA (American Diabetes Association).
He admits there that low carbohydrate diet provides better blood sugar control in diabetics.
But then he says that ADA does not recommend low carbohydrate diet because diabetics do not like to eat the diet.
ADA will therefore continue to recommend high carbohydrate diet, although it is much worse for the diabetic’s health, because the ADA believes that the diabetics would not like to eat low carbohydrate diet. (Or fail to adhere to the diet, which for me means the same thing)
ADA:s mission is to be unlikely to guess what diabetics like to eat, but their role must be to tell what the best science shows to be the best diet for diabetics health!
This following article is also on the clinical outcome regarding heart disease and cardio vascular events can be prevented by low carbohydrate diet.
Written by Annika Dahlqvist on 18 June, 2006 at 14:51
The article by Jörgen Vesti Nielsen and Eva Jönsson about 22 months follow up of Karlshamn study: http://www.nutritionandmetabolism.com/content/pdf/1743-7075-3-22.pdf you find a passage on the clinical outcome of the subject.
It is said that the 5 people in the control group who did not change from Low lipid to low carbohydrate diet has 3 had cardiovascular events (myocardial infarction or heart failure).
The 23 people who either were part of the original low carbohydrate group or shifted to low carbohydrate did not experience any cardiovascular events during the observation period.
These figures speak against the anticipated risk of heart disease if you eat more saturated lipid than the current low lipid diet recommendation.
And how they got kidney failure to reverse with low carbohydrate diet. http://blogg.passagen.se/dahlqvistannika/?anchor=l%C3%A5gkolhydratkost_kan_f%C3%B6rb%C3%A4ttra_njurfunktionen_hos:
A low-carbohydrate diet may prevent end-stage renal failure in type 2 diabetes. A case report by Jorgen Vesti Nielsen, Per Westerlund and Per G Bygren
Nutrition & Metabolism 2006, 3:23 doi:10.1186/1743-7075-3-23
Published 14 June, 2006
Abstract (provisional)
An obese patient with type 2 diabetes whose diet was changed from the recommended high-carbohydrate, low-fat type to a low-carbohydrate diet showed a significant reduction in bodyweight, improved glycemic control and a reversal of a six year long decline of renal function. The reversal of the renal function was likely caused by both improved glycemic control and elimination of the patient’s obesity. Insulin treatment in type 2 diabetes patients usually leads to weight increase which may cause further injury to the kidney.
Although other unknown metabolic mechanisms cannot be excluded, it is likely that the obesity caused by the combination of high-carbohydrate diet and insulin in this case contributed to the patients deteriorating kidney function. In such patients, where control of bodyweight and hyperglycaemia is vital, a trial with a low-carbohydrate diet may be appropriate to avoid the risk of adding obesity-associated renal failure to already failing kidneys.
Written by Annika Dahlqvist on 22 May,2008
Now the results of 44 months have occurred.
Of the 23 people who ate low carbohydrate diet (20 %) two had heart disease.
Of 5 people who had eaten low lipid diet according to the dietician’s instructions 4 had had heart disease.
I have written more about the study in the following post:
Karlshamns study 44 months
Written by Annika Dahlqvist on 22 May, 2008 at 16:34
Now the report from the Karlshamn study 44 months has come. It is 3, 6 years. http://www.nutritionandmetabolism.com/content/5/1/14 .
Of the 23 people who ate low carbohydrate diet (20 %) two had had heart disease. There will be 8 %. Of the five people who ate according to the dietician’s instructions four had had heart disease. There will be 80 %.
One person in the low carbohydrate group has died. He had no known heart disease, and the autopsy did not show it. The cause of death was unknown.
Two persons have died in the low lipid group, they had known heart disease. The person who died and the two who had heart attacks, in the LC group, had according to a personal message from Jorgen not eaten lowcarb according to the program. It can of course as we all know be hard to keep low carbohydrate diet, there are so many temptations. When you give in to temptation once and the craving comes as a letter in the mail, and then it will be even more difficult.
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Press comments on the 44 months report. Reuters reports from the Karlshamn study.
Written by Annika Dahlqvist on 29 May, 2008 at 13:19
Low-Carb diets work for overweight diabetics http://www.reuters.com/article/idUSCOL86412020080528?sp=true
In Dagens Nyheter about the study. http://www.reuters.com/article/idUSCOL86412020080528?sp=true
Who does research?
Written by Annika Dahlqvist on 29 May, 2008 at 10:18
Anna Ottosson writes in her blog http://www.annaottosson.se/blogg/?p=8#comments that LCHF is an interesting spin, but ”…….. I would like to see scientific evidence over the long term effects of LCHF from serious scientific journals.” Who should do this scientific documentation? Long term it should be. Is it the district doctor, who had to resign from her post due to dietary issue, which should make them?
Perhaps there are ongoing studies in Sweden’s country, or in another country, on this. It won’t be known until they are ready. Diabetics should accordingly wait until the established researchers have been inspired to make these studies, and made them long enough to be considered long term.
If you scrutinize scientific research it is considered that a dietary study to be comparative with as few variables as possible. An example would be to study different proportions of dietary lipids versus carbohydrates. Another example is to compare natural lipid with industrial grease.
Studies shall also be controlled, ie it should, as far as you can what subjects eat. This is usually done by food diaries. Otherwise, you must have the subjects confined in an institution and it is not practical and economically feasible on a larger scale and longer. It is also said to be deprived groups, so called randomization. The point is difficult because many people have an idea of what is healthy eating, and then it can be difficult for them to stick to a different diet.
Therefore, it will be more decisive on the choice of subjects for which diet program they should eat. Otherwise is that they continue to eat as they normally do. It is still just as interesting to see how it goes for those who eat a certain diet.
These unifactorial diet studies can usefully be made on the disease Type-2 diabetes and cardiovascular illness. Then you can get quick answers. For instance, the Karlshamn study gave significant difference to the advantage of the low carbohydrate diet already after six months.
After 44 months report there was still significant differences. 80% of low lipid group had heart disease, but only 8% of low carbohydrate group. The mortality was also higher in the low lipid group. This should give rise to many more similar studies.
In the meantime, diabetics should be advised to eat low carbohydrate diets, because the comparative studies are showing the benefit of it. There is yet no comparative study on low lipid versus low carbohydrate showing superior efficacy for low lipid diet. The establishment says that there is scientific evidence to recommend low lipid, and margarines, according to the plate model and keyhole label, but that is a lie. There is as yet no comparative studies that support it, how serious the journals these studies are published in.
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